Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Estrogen is an essential sex steroid hormone that functions primarily in female reproductive
system, as well as in a variety of tissues and organs with pleiotropic effects, such as in …

Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases …

Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke.
Despite highly heritable etiology, our understanding of the genetic architecture of AF …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Pluripotent stem cells (PSCs) can undergo unlimited self-renewal and can differentiate into
all the cell types present in our body, including cardiomyocytes. Therefore, PSCs can be an …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein
isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we …

Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of
cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we …

The heart is a highly metabolic organ that uses multiple energy sources to meet its demand
for ATP production. Diurnal feeding–fasting cycles result in fluctuations in substrate …