• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Importance Obesity affects approximately 42% of US adults and is associated with increased
rates of type 2 diabetes, hypertension, cardiovascular disease, sleep disorders …

Background Obesity and type 2 diabetes are prevalent in patients with heart failure with
preserved ejection fraction and are characterized by a high symptom burden. No approved …

Importance The effect of continued treatment with tirzepatide on maintaining initial weight
reduction is unknown. Objective To assess the effect of tirzepatide, with diet and physical …

Background Obesity increases the risk of heart failure with preserved ejection fraction.
Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and …

BACKGROUND Reducing the levels of triglycerides and triglyceride-rich lipoproteins
remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting …

Importance Thirteen human malignant neoplasms have been identified as obesity-
associated cancers (OACs), ie, the presence of excess body fat is associated with increased …

Importance Obesity affects approximately 19% of women and 14% of men worldwide and is
associated with increased morbidity. Antiobesity medications (AOMs) modify biological …

Importance Anecdotal experience raised the possibility that semaglutide, a glucagon-like
peptide 1 receptor agonist (GLP-1 RA) with rapidly increasing use, is associated with …

Background SGLT2 inhibitors and GLP-1 receptor agonists both improve cardiovascular and
kidney outcomes in patients with type 2 diabetes. We sought to evaluate whether the …