Overview of histone modification
Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …
parents to offspring. From years of studies, people have found that histone modifications …
[HTML][HTML] The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
[HTML][HTML] Molecular map of chronic lymphocytic leukemia and its impact on outcome
Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
[HTML][HTML] Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Histone exchange, chromatin structure and the regulation of transcription
S Venkatesh, JL Workman - Nature reviews Molecular cell biology, 2015 - nature.com
The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
Chromatin and nucleosome dynamics in DNA damage and repair
Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …
interphase nuclei. Different categories of specialized enzymes act on chromatin and …
[HTML][HTML] Histone variants on the move: substrates for chromatin dynamics
PB Talbert, S Henikoff - Nature reviews Molecular cell biology, 2017 - nature.com
Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …
Post-translational modifications of histones that influence nucleosome dynamics
GD Bowman, MG Poirier - Chemical reviews, 2014 - ACS Publications
Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
[HTML][HTML] Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
GJ Narlikar, R Sundaramoorthy, T Owen-Hughes - Cell, 2013 - cell.com
Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …
small space and a means to package the same genetic material in different chromatin states …
Histone variants and epigenetics
S Henikoff, MM Smith - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …