Single-cell multiomics decodes regulatory programs for mouse secondary palate development

F Yan, A Suzuki, C Iwaya, G Pei, X Chen… - Nature …, 2024 - nature.com
Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is
among the most common congenital birth defects. Here, we perform single-cell multiome …

FaceBase: a community-driven hub for data-intensive research

RE Schuler, A Bugacov, JG Hacia… - Journal of Dental …, 2022 - journals.sagepub.com
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial
Research of the National Institutes of Health, was established in 2009 with the recognition …

Analysis of exome data in a UK cohort of 603 patients with syndromic orofacial clefting identifies causal molecular pathways

K Wilson, DF Newbury, U Kini - Human Molecular Genetics, 2023 - academic.oup.com
Orofacial cleft (OC) is a common congenital anomaly in humans, which has lifelong
implications for affected individuals. This disorder can be classified as syndromic or non …

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors

G Qin, S Mallik, R Mitra, A Li, P Jia, CM Eischen… - Scientific Reports, 2020 - nature.com
Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have
synergistic roles in cellular systems and their disruption may cause diseases including …

Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA–TF–gene network approach in humans and mice

A Li, P Jia, S Mallik, R Fei, H Yoshioka… - Briefings in …, 2020 - academic.oup.com
Cleft palate (CP) is the second most common congenital birth defect. The etiology of CP is
complicated, with involvement of various genetic and environmental factors. To investigate …

A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development

F Yan, P Jia, H Yoshioka, A Suzuki, J Iwata… - …, 2020 - journals.biologists.com
Craniofacial development is regulated through dynamic and complex mechanisms that
involve various signaling cascades and gene regulations. Disruption of such regulations can …

miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence

S Nersisyan, A Galatenko, V Galatenko, M Shkurnikov… - PLoS …, 2021 - journals.plos.org
Analysis of regulatory networks is a powerful framework for identification and quantification
of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA …

mir152 hypomethylation as a mechanism for non-syndromic cleft lip and palate

L Alvizi, LA Brito, GS Kobayashi, B Bischain… - Epigenetics, 2022 - Taylor & Francis
Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human
craniofacial malformation, is a complex disorder given its genetic heterogeneity and …

Spatiotemporal microRNA-gene expression network related to orofacial clefts

F Yan, LM Simon, A Suzuki, C Iwaya… - Journal of Dental …, 2022 - journals.sagepub.com
Craniofacial structures change dynamically in morphology during development through the
coordinated regulation of various cellular molecules. However, it remains unclear how these …

Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice

H Yoshioka, A Li, A Suzuki… - Human Molecular …, 2021 - academic.oup.com
The etiology of cleft lip with/without cleft palate (CL/P), one of the most frequent craniofacial
birth defects worldwide, is complicated by contributions of both genetic and environmental …