Single-cell multiomics decodes regulatory programs for mouse secondary palate development
Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is
among the most common congenital birth defects. Here, we perform single-cell multiome …
among the most common congenital birth defects. Here, we perform single-cell multiome …
FaceBase: a community-driven hub for data-intensive research
RE Schuler, A Bugacov, JG Hacia… - Journal of Dental …, 2022 - journals.sagepub.com
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial
Research of the National Institutes of Health, was established in 2009 with the recognition …
Research of the National Institutes of Health, was established in 2009 with the recognition …
Analysis of exome data in a UK cohort of 603 patients with syndromic orofacial clefting identifies causal molecular pathways
K Wilson, DF Newbury, U Kini - Human Molecular Genetics, 2023 - academic.oup.com
Orofacial cleft (OC) is a common congenital anomaly in humans, which has lifelong
implications for affected individuals. This disorder can be classified as syndromic or non …
implications for affected individuals. This disorder can be classified as syndromic or non …
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors
Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have
synergistic roles in cellular systems and their disruption may cause diseases including …
synergistic roles in cellular systems and their disruption may cause diseases including …
Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA–TF–gene network approach in humans and mice
Cleft palate (CP) is the second most common congenital birth defect. The etiology of CP is
complicated, with involvement of various genetic and environmental factors. To investigate …
complicated, with involvement of various genetic and environmental factors. To investigate …
A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development
Craniofacial development is regulated through dynamic and complex mechanisms that
involve various signaling cascades and gene regulations. Disruption of such regulations can …
involve various signaling cascades and gene regulations. Disruption of such regulations can …
miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence
Analysis of regulatory networks is a powerful framework for identification and quantification
of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA …
of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA …
mir152 hypomethylation as a mechanism for non-syndromic cleft lip and palate
Non-syndromic cleft lip with or without cleft palate (NSCLP), the most common human
craniofacial malformation, is a complex disorder given its genetic heterogeneity and …
craniofacial malformation, is a complex disorder given its genetic heterogeneity and …
Spatiotemporal microRNA-gene expression network related to orofacial clefts
Craniofacial structures change dynamically in morphology during development through the
coordinated regulation of various cellular molecules. However, it remains unclear how these …
coordinated regulation of various cellular molecules. However, it remains unclear how these …
Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice
The etiology of cleft lip with/without cleft palate (CL/P), one of the most frequent craniofacial
birth defects worldwide, is complicated by contributions of both genetic and environmental …
birth defects worldwide, is complicated by contributions of both genetic and environmental …