The selfish network: how the brain preserves behavioral function through shifts in neuronal network state
Neuronal networks possess the ability to regulate their activity states in response to
disruptions. How and when neuronal networks turn from physiological into pathological …
disruptions. How and when neuronal networks turn from physiological into pathological …
Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease
OG Bhalala, R Watson, N Yassi - International Journal of Molecular …, 2024 - mdpi.com
Late-onset Alzheimer's disease is the leading cause of dementia worldwide, accounting for
a growing burden of morbidity and mortality. Diagnosing Alzheimer's disease before …
a growing burden of morbidity and mortality. Diagnosing Alzheimer's disease before …
Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegeneration
R Hobson, SHS Levy, D Flaherty, H Xiao, B Ciener… - BioRxiv, 2023 - biorxiv.org
Recent murine studies have highlighted a crucial role for the meninges in surveilling the
central nervous system (CNS) and influencing CNS inflammation. However, how meningeal …
central nervous system (CNS) and influencing CNS inflammation. However, how meningeal …
Blood‐Based Proteomics for Adult‐Onset Focal Dystonias
J Timsina, A Dinasarapu, G Kilic‐Berkmen… - Annals of …, 2024 - Wiley Online Library
Objectives The adult‐onset focal dystonias are characterized by over‐active muscles
leading to abnormal movements. For most cases, the etiology and pathogenesis remain …
leading to abnormal movements. For most cases, the etiology and pathogenesis remain …
[HTML][HTML] Proteomic Network Analysis of Alzheimer's Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
Alzheimer's disease (AD) is currently defined at the research level by the aggregation of
amyloid-β (Aβ) and tau proteins in brain. While biofluid biomarkers are available to measure …
amyloid-β (Aβ) and tau proteins in brain. While biofluid biomarkers are available to measure …
[HTML][HTML] Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations
METHODS: To bridge this gap, Accelerating Medicines Partnership in AD (AMP-AD)
expanded brain multi-omics profiling to multi-ethnic donors. RESULTS: We generated multi …
expanded brain multi-omics profiling to multi-ethnic donors. RESULTS: We generated multi …
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease
We report a highly significant correlation in brain proteome changes between Alzheimers
disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein …
disease (AD) and CRND8 APP695NL/F transgenic mice. However, integrating protein …
Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome
INTRODUCTION This study aimed to investigate the influence of the overall Alzheimer's
disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and …
disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and …
Global analysis of the heparin-enriched plasma proteome captures matrisome-associated proteins in Alzheimer's disease
Matrisome-associated heparin binding proteins (HBPs) with roles in extracellular matrix
assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease …
assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease …
Systematic proteomics in Autosomal dominant Alzheimer's disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways
Background To date, there is no high throughput proteomic study in the context of Autosomal
Dominant Alzheimers disease (ADAD). Here, we aimed to characterize early CSF proteome …
Dominant Alzheimers disease (ADAD). Here, we aimed to characterize early CSF proteome …