Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages
by host and viral proteases in order to produce the individual proteins that constitute an …

Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the
context of maternal infection during pregnancy. An important target for drugs combatting Zika …

Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus
(YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne …

Flaviviruses causes significant human disease. Recent outbreaks of the Zika virus highlight
the need to develop effective therapies for this class of viruses. Previously we identified …

Dengue virus is an important human pathogen threating people, especially in tropical and
sub-tropical regions. The viral genome has one open reading frame and encodes one …

Dengue virus (DENV) is a danger to more than 400 million people in the world, and there is
no specific treatment. Thus, there is an urgent need to develop an effective method to …