Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess
cerebrovascular function. The brain is unique in its high energy and oxygen demand but …

Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory
or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between …

Heat stress increases human morbidity and mortality compared to normothermic conditions.
Many occupations, disease states, as well as stages of life are especially vulnerable to the …

Non‐technical summary Two mechanisms control brain blood flow by changing blood
vessel diameter: autoregulation maintains flow in the face of perfusion pressure changes …

Cerebral autoregulation (CA) is integral to the delicate process of maintaining stable
cerebral perfusion and brain tissue oxygenation against changes in arterial blood pressure …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Key points• Arterial CO2 serves as a mediator of cerebral blood flow, and its relative
influence on the regulation of cerebral blood flow is defined as cerebral CO2 reactivity.• …

Background How phenylephrine and ephedrine treatments affect global and regional
haemodynamics is of major clinical relevance. Cerebral tissue oxygen saturation ()-guided …