Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …

Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that
express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells …

The incidence of colorectal cancer (CRC) is on the rise, and the prognosis for patients with
recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation …

Emerging evidence on the role of the antitumor activity of the immune system has generated
great interest in immunotherapy even for tumors that were historically considered as …

Much effort has been expended in the search for inhibitors of signalling molecules that may
prove to be important therapeutically in cancer. The epidermal growth factor receptor …

Abstract Purpose of Review In this review, we analyzed the current landscape of non-PD-(L)
1 targeting immunotherapy. Recent Findings The advent of immunotherapy has completely …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the molecular biology of epidermal growth factor receptor (EGFR) function in malignant cells …

Purpose: EGFR is a well-validated target for patients with non–small cell lung cancer
(NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant …

NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a
saponin-based adjuvant that induces antibody and T cell responses. We performed a …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …