Pregnancy may be the most nutritionally sensitive stage in the life cycle, and improved
metabolic health during gestation and early postnatal life can reduce the risk of chronic …

Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of
morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE …

Fetal growth restriction (FGR) in pregnancy is commonly caused by impaired uteroplacental
blood flow. Vasodilators enhance uteroplacental perfusion and fetal growth in humans and …

Fetal growth restriction (FGR) in human pregnancy is associated with perinatal mortality,
short-and long-term morbidities. No prenatal therapy is currently established despite …

Maternal mortality rates are at an all-time high across the world and are set to increase in
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …

The anti-angiogenic soluble fms-like tyrosine kinase 1 (sFLT1) is one of the candidates in
the progression of preeclampsia, often associated with fetal growth restriction (FGR) …

Pre-eclampsia is a multifactorial pregnancy-associated disorder characterized by
angiogenic dysbalance and systemic inflammation; however, animal models that combine …

Preeclampsia remains a clinical challenge due to its poorly understood pathogenesis. A
prevailing notion is that increased placental production of soluble fms-like tyrosine kinase-1 …

Key points Pregnancy at high altitude is associated with a greater incidence of fetal growth
restriction due, in part, to lesser uterine artery blood flow. AMP‐activated protein kinase …

Objectives To evaluate the effect of phosphodiesterase-5 (PDE-5) inhibitors on
uteroplacental and fetal cerebral perfusion in pregnancies complicated with fetal growth …