International union of basic and clinical pharmacology. CI. Structures and small molecule modulators of mammalian adenylyl cyclases
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …
[HTML][HTML] Isoforms of mammalian adenylyl cyclase: multiplicities of signaling
RK Sunahara, R Taussig - Molecular interventions, 2002 - triggered.edina.clockss.org
Mechanistic descriptions of cAMP production have evolved significantly since the 1960s
when Sutherland and Rall hypothesized the existence of a single polypeptide that would …
when Sutherland and Rall hypothesized the existence of a single polypeptide that would …
RGD-functionalized bioengineered spider dragline silk biomaterial
E Bini, CWP Foo, J Huang, V Karageorgiou… - …, 2006 - ACS Publications
Spider silk fibers have remarkable mechanical properties that suggest the component
proteins could be useful biopolymers for fabricating biomaterial scaffolds for tissue …
proteins could be useful biopolymers for fabricating biomaterial scaffolds for tissue …
Novel nanocomposites from spider silk–silica fusion (chimeric) proteins
C Wong Po Foo, SV Patwardhan… - Proceedings of the …, 2006 - National Acad Sciences
Silica skeletal architectures in diatoms are characterized by remarkable morphological and
nanostructural details. Silk proteins from spiders and silkworms form strong and intricate self …
nanostructural details. Silk proteins from spiders and silkworms form strong and intricate self …
Spider silk-based gene carriers for tumor cell-specific delivery
The present study demonstrates pDNA complexes of recombinant silk proteins containing
poly (l-lysine) and tumor-homing peptides (THPs), which are globular and approximately …
poly (l-lysine) and tumor-homing peptides (THPs), which are globular and approximately …
Bioengineered silk protein-based gene delivery systems
Silk proteins self-assemble into mechanically robust material structures that are also
biodegradable and non-cytotoxic, suggesting utility for gene delivery. Since silk proteins can …
biodegradable and non-cytotoxic, suggesting utility for gene delivery. Since silk proteins can …
Designing chimeric molecules for drug discovery by leveraging chemical biology
After the first seed concept introduced in the 18th century, different disciplines have
attributed different names to dual-functional molecules depending on their application …
attributed different names to dual-functional molecules depending on their application …
Antimicrobial functionalized genetically engineered spider silk
Genetically engineered fusion proteins offer potential as multifunctional biomaterials for
medical use. Fusion or chimeric proteins can be formed using recombinant DNA technology …
medical use. Fusion or chimeric proteins can be formed using recombinant DNA technology …
Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds
CS Brand, HJ Hocker, AA Gorfe, CN Cavasotto… - … of Pharmacology and …, 2013 - ASPET
Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the
second messenger cyclic AMP (cAMP) in response to various stimuli. Reduction of AC …
second messenger cyclic AMP (cAMP) in response to various stimuli. Reduction of AC …
Gene delivery mediated by recombinant silk proteins containing cationic and cell binding motifs
K Numata, J Hamasaki, B Subramanian… - Journal of controlled …, 2010 - Elsevier
Silk proteins are biodegradable and biocompatible, and can also be tailored to contain
additional features via genetic engineering, suggesting utility for gene delivery. In the …
additional features via genetic engineering, suggesting utility for gene delivery. In the …