Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke

P Jolugbo, RAS Ariëns - Stroke, 2021 - Am Heart Assoc
Thrombi retrieved from patients with acute ischemic stroke are highly heterogeneous.
Recent data suggest that thrombus composition may impact on mechanical thrombectomy …

Thrombus structural composition in cardiovascular disease

G Alkarithi, C Duval, Y Shi, FL Macrae… - … , and vascular biology, 2021 - Am Heart Assoc
Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Neutrophil extracellular traps in ischemic stroke thrombi

E Laridan, F Denorme, L Desender… - Annals of …, 2017 - Wiley Online Library
Objective Neutrophil extracellular traps (NETs) have been shown to promote thrombus
formation. Little is known about the exact composition of thrombi that cause ischemic stroke …

Inflammatory disequilibrium in stroke

D Petrovic-Djergovic, SN Goonewardena… - Circulation …, 2016 - Am Heart Assoc
Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Thrombus histology suggests cardioembolic cause in cryptogenic stroke

T Boeckh-Behrens, JF Kleine, C Zimmer, F Neff… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Ischemic stroke of undetermined cause is a major health issue
because of its high frequency and clinical relevance. Histopathologic analysis of human …

Ischemic stroke: what does the histological composition tell us about the origin of the thrombus?

PB Sporns, U Hanning, W Schwindt, A Velasco… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—The introduction of stent retrievers allows for a complete
extraction and histological analysis of human thrombi. Ischemic stroke is a major health …

CT and MRI early vessel signs reflect clot composition in acute stroke

DS Liebeskind, N Sanossian, WH Yong, S Starkman… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—The purpose of this study was to provide the first correlative
study of the hyperdense middle cerebral artery sign (HMCAS) and gradient-echo MRI …

Clot friction variation with fibrin content; implications for resistance to thrombectomy

GM Gunning, K McArdle, M Mirza, S Duffy… - Journal of …, 2018 - jnis.bmj.com
Background Despite significant advancements in the procedural efficacy of mechanical
thrombectomy in patients with ischemic stroke in recent years, there still remains a portion of …

Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review

W Brinjikji, S Duffy, A Burrows, W Hacke… - Journal of …, 2017 - jnis.bmj.com
Background and purpose Studying the imaging and histopathologic characteristics of
thrombi in ischemic stroke could provide insights into stroke etiology and ideal treatment …

Association of time from stroke onset to groin puncture with quality of reperfusion after mechanical thrombectomy: a meta-analysis of individual patient data from 7 …

R Bourcier, M Goyal, DS Liebeskind, KW Muir… - JAMA …, 2019 - jamanetwork.com
Importance Reperfusion is a key factor for clinical outcome in patients with acute ischemic
stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial …