This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Nitric oxide is an inorganic free radical gas, of formula* N= O (abbreviated as NO). The
discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L …

Nitric oxide synthases (NOSs)'(L-arginine, NADPH: oxygen oxidoreductases (nitric oxide
forming); EC 1.14. 13.39) are unique among eukaryotic enzymes in being dimeric …

Vasodilation and increased blood flow are characteristic early vascular responses to acute
hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently
of an increase in Ca2+ by the phosphorylation of Ser1177 but results only in a low nitric …

NO was first characterized in the CNS as the intercellular messenger mediating the increase
in cyclic GMP levels that follows activation of glutamate receptors (Garthwaite et al., 1988) …

This review briefly summarizes what was known about NOS enzymology at the time of the
Nobel Prize award in 1998 and then discusses from the author's perspective some of the …