High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

[HTML][HTML] Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review

E Maverakis, K Kim, M Shimoda, ME Gershwin… - Journal of …, 2015 - Elsevier
Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …

Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

[HTML][HTML] High-mannose glycans are elevated during breast cancer progression

MLA De Leoz, LJT Young, HJ An… - Molecular & Cellular …, 2011 - ASBMB
Alteration in glycosylation has been observed in cancer. However, monitoring glycosylation
changes during breast cancer progression is difficult in humans. In this study, we used a well …

[HTML][HTML] Cancer biomarkers: are we ready for the prime time?

A Mishra, M Verma - Cancers, 2010 - mdpi.com
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of
normal biologic processes, pathogenic processes, or pharmacologic responses to a …

Glycomics and disease markers

HJ An, SR Kronewitter, MLA de Leoz… - Current opinion in …, 2009 - Elsevier
Glycomics is the comprehensive study of all glycans expressed in biological systems. The
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …

N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients

WR Alley Jr, JA Vasseur, JA Goetz… - Journal of proteome …, 2012 - ACS Publications
Glycosylated proteins play important roles in a broad spectrum of biochemical and biological
processes, and prior reports have suggested that changes in protein glycosylation occur …

Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges

ME Huflejt, M Vuskovic, D Vasiliu, H Xu… - Molecular …, 2009 - Elsevier
We have used microchip format glycan array to characterize the individual carbohydrate
recognition patterns by antibodies (Ab) in sera of 106 healthy donors. The glycan library …

Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles

Z Kyselova, Y Mechref, P Kang, JA Goetz… - Clinical …, 2008 - academic.oup.com
Background: Glycosylated proteins play important roles in cell-to-cell interactions,
immunosurveillance, and a variety of receptor-mediated and specific protein functions …