Dithiocarbamates are highly versatile mono-anionic chelating ligands which form stable
complexes with all the transition elements and also the majority of main group, lanthanide …

Supervised intake of the alcohol deterrent (AD) disulfiram has proven to be an effective
adjunct to biopsychosocial alcoholism therapy for more than 60 years. This article …

Background Despite its success with compliant or supervised patients, disulfiram has been a
controversial medication in the treatment of alcoholism. Often, study designs did not …

Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy
resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity …

The British Association for Psychopharmacology guidelines for the treatment of substance
abuse, harmful use, addiction and comorbidity with psychiatric disorders primarily focus on …

Previous studies have demonstrated that breast cancer cells deploy a myriad array of
strategies to thwart the activity of anticancer drugs like docetaxel (DTX), including acquired …

There are an estimated several million crack-cocaine users globally; use is highest in the
Americas. Most crack users are socio-economically marginalized (eg, homeless), and …

Background Cocaine is a psychostimulant used by approximately 0.4% of the general
population worldwide. Cocaine dependence is a chronic mental disorder characterised by …

Disulfiram treatment, despite its limitations, remains a viable option as a treatment for
alcohol dependence and has shown recent promise in treating (1) those with co-morbid …

Background The development of alcohol dependence is associated with significant
morbidity and mortality. For the majority of affected people the most appropriate goal, in …