Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

To further increase the production efficiency of microbial shikimate, a valuable compound
widely used in the pharmaceutical and chemical industries, ten key target genes contributing …

Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities
for modern biotechnology. High-performance cell factories, the backbone of industrial …

Genetic elements are foundational in synthetic biology serving as vital building blocks. They
enable programming host cells for efficient production of valuable chemicals and …

Saccharomyces cerevisiae is an excellent microbial cell factory for producing valuable
recombinant proteins because of its fast growth rate, robustness, biosafety, ease of …

Microbial proteins are promising substitutes for animal-and plant-based proteins. S.
cerevisiae, a generally recognized as safe (GRAS) microorganism, has been frequently …

Saccharomyces cerevisiae is a robust cell factory to secrete or surface-display cellulase and
amylase for the conversion of agricultural residues into valuable chemicals. Engineering the …

The successful expression and secretion of recombinant proteins in cell factories
significantly depend on the correct folding of nascent peptides, primarily achieved through …

The increased prevalence of diabetes and the growing popularity of non-invasive methods
of recombinant human insulin uptake, such as oral insulin, have increased insulin demand …