Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential
for numerous cellular processes including enzymatic reactions, ion channel functions …

Magnesium is the most abundant intracellular divalent cation and essential for maintaining
normal cellular physiology and metabolism, acting as a cofactor of numerous enzymes …

Reperfusion injury is an inherent response to the restoration of blood flow after ischemia. It is
a complex process involving numerous mechanisms occurring in the intracellular and …

Ethnopharmacological relevance Cardiac fibrosis is a common characteristic of many
cardiac diseases. Our previous results showed that TRPM7 channel played an important …

Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from
the primary tumor to distant organs. At the molecular level, migration is the result of several …

Mg2+ plays a vital role in platelet function, but despite implications for life-threatening
conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg2+] i in …

DNA polymerase θ (Polθ) promotes insertion mutations during alternative end-joining (alt-
EJ) by an unknown mechanism. Here, we discover that mammalian Polθ transfers …