Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …
complexes could play a more significant role in human cancer therapy. However, targeting …
Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view
Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
SK Wculek, I Heras-Murillo, A Mastrangelo, D Mañanes… - Immunity, 2023 - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers
K Chen, P Lu, NM Beeraka, OA Sukocheva… - Seminars in cancer …, 2022 - Elsevier
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release
DB Zorov, M Juhaszova, SJ Sollott - Physiological reviews, 2014 - journals.physiology.org
Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …
[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Novel Pathway for Vanadium(V) Bio-Detoxification by Gram-Positive Lactococcus raffinolactis
B Zhang, Y Li, Y Fei, Y Cheng - Environmental Science & …, 2021 - ACS Publications
Whereas prospects of bioremediation for a vanadium (V)[V (V)]-contaminated environment
are widely recognized, reported functional species are extremely limited, with the vast …
are widely recognized, reported functional species are extremely limited, with the vast …
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …
The role of the electron transport chain in immunity
M Yin, LAJ O'Neill - The FASEB journal, 2021 - Wiley Online Library
The electron transport chain (ETC) couples oxidative phosphorylation (OXPHOS) with ATP
synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has …
synthase to drive the generation of ATP. In immune cells, research surrounding the ETC has …
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Recent sequencing studies have extensively explored the somatic alterations present in the
nuclear genomes of cancers. Although mitochondria control energy metabolism and …
nuclear genomes of cancers. Although mitochondria control energy metabolism and …