[HTML][HTML] Overcoming challenges in glioblastoma treatment: targeting infiltrating cancer cells and harnessing the tumor microenvironment
Glioblastoma (GB) is a highly malignant primary brain tumor with limited treatment options
and poor prognosis. Despite current treatment approaches, including surgical resection …
and poor prognosis. Despite current treatment approaches, including surgical resection …
[HTML][HTML] Injury programs shape glioblastoma
Glioblastoma is the most common and aggressive primary brain cancer in adults and is
almost universally fatal due to its stark therapeutic resistance. During the past decade …
almost universally fatal due to its stark therapeutic resistance. During the past decade …
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of
phenotypic and activation states. We now have limited knowledge of the tumor …
phenotypic and activation states. We now have limited knowledge of the tumor …
[HTML][HTML] The Interplay between Glioblastoma Cells and Tumor Microenvironment: New Perspectives for Early Diagnosis and Targeted Cancer Therapy
Glioblastoma multiforme (GBM) stands out as the most tremendous brain tumor, constituting
60% of primary brain cancers, accompanied by dismal survival rates. Despite advancements …
60% of primary brain cancers, accompanied by dismal survival rates. Despite advancements …
[HTML][HTML] The tumour ecology of quiescence: Niches across scales of complexity
Quiescence is a state of cell cycle arrest, allowing cancer cells to evade anti-proliferative
cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment …
cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment …
[HTML][HTML] Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
V Amodeo, T Davies, A Martinez-Segura… - Developmental Cell, 2023 - cell.com
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone
that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting …
that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting …
[HTML][HTML] Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion
N Alshahrany, A Begum, D Siebzehnrubl… - Cancer Letters, 2023 - Elsevier
Glioblastoma is the most lethal brain cancer in adults. These incurable tumors are
characterized by profound heterogeneity, therapy resistance, and diffuse infiltration. These …
characterized by profound heterogeneity, therapy resistance, and diffuse infiltration. These …
[HTML][HTML] Current Status and Future Perspective in Glioma Invasion Research
T Ohnishi - Brain Sciences, 2024 - mdpi.com
Glioblastoma (GBM) is the most malignant brain tumor in adults and shows an extremely
poor prognosis, with a median survival of 15 months [1]. The main reason for this poor …
poor prognosis, with a median survival of 15 months [1]. The main reason for this poor …
[HTML][HTML] Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
[HTML][HTML] Unveiling cancer dormancy: intrinsic mechanisms and extrinsic forces
Tumor cells disseminate in various distant organs at early stages of cancer progression.
These disseminated tumor cells (DTCs) can stay dormant/quiescent without causing patient …
These disseminated tumor cells (DTCs) can stay dormant/quiescent without causing patient …