Allergic rhinitis and its impact on asthma

J Bousquet, P Van Cauwenberge… - Journal of allergy and …, 2001 - jacionline.org
Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

Immunological mechanisms of allergen-specific immunotherapy

M Larché, CA Akdis, R Valenta - Nature Reviews Immunology, 2006 - nature.com
Allergen-specific immunotherapy has been carried out for almost a century and remains one
of the few antigen-specific treatments for inflammatory diseases. The mechanisms by which …

EAACI molecular allergology user's guide 2.0

S Dramburg, C Hilger, AF Santos… - Pediatric Allergy and …, 2023 - Wiley Online Library
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

EAACI molecular allergology user's guide

PM Matricardi, J Kleine‐Tebbe… - Pediatric Allergy and …, 2016 - Wiley Online Library
The availability of allergen molecules ('components') from several protein families has
advanced our understanding of immunoglobulin E (IgE)‐mediated responses and enabled …

A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

K Melcher, LM Ng, XE Zhou, FF Soon, Y Xu… - Nature, 2009 - nature.com
Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and
responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of …

Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs

J Santiago, A Rodrigues, A Saez, S Rubio… - The Plant …, 2009 - Wiley Online Library
Abscisic acid (ABA) is a key phytohormone involved in adaption to environmental stress and
regulation of plant development. Clade A protein phosphatases type 2C (PP2Cs), such as …

Structural mechanism of abscisic acid binding and signaling by dimeric PYR1

N Nishimura, K Hitomi, AS Arvai, RP Rambo, C Hitomi… - Science, 2009 - science.org
The phytohormone abscisic acid (ABA) acts in seed dormancy, plant development, drought
tolerance, and adaptive responses to environmental stresses. Structural mechanisms …

Current understanding of cross‐reactivity of food allergens and pollen

S Vieths, S Scheurer… - Annals of the New York …, 2002 - Wiley Online Library
Pollen‐allergic patients frequently present allergic symptoms after ingestion of several kinds
of plant‐derived foods. The majority of these reactions is caused by four distinct cross …

Structural and functional aspects of PR‐10 proteins

H Fernandes, K Michalska, M Sikorski… - The FEBS …, 2013 - Wiley Online Library
Physical, chemical and biological stress factors, such as microbial infection, upregulate the
transcription levels of a number of plant genes, coding for the so‐called pathogenesis …

Modelling dynamics in protein crystal structures by ensemble refinement

BT Burnley, PV Afonine, PD Adams, P Gros - elife, 2012 - elifesciences.org
Single-structure models derived from X-ray data do not adequately account for the inherent,
functionally important dynamics of protein molecules. We generated ensembles of structures …