The ubiquitin-proteasome pathway (UPP) has multiple roles in the normal nervous system,
including the development of synaptic connections and synaptic plasticity. Research over …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in
tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt …

The control of Wnt receptor abundance is critical for animal development and to prevent
tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We …

As the primary mediator for synaptic transmission, AMPA receptors (AMPARs) are crucial for
synaptic plasticity and higher brain functions. A downregulation of AMPAR expression has …

The molecular mechanisms underlying plastic changes in the strength and connectivity of
excitatory synapses have been studied extensively for the past few decades and remain the …

UBE3A gene copy number variation and the resulting overexpression of the protein E6AP is
directly linked to autism spectrum disorders (ASDs). However, the underlying cellular and …

De novo mutations and copy number deletions in NRXN1 (2p16. 3) pose a significant risk for
schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a …

Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly
conserved among eukaryotes) to itself or to other proteins through differential use of …

Dynamic changes in synaptic strength rely on de novo protein synthesis and protein
degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular …