▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

MHC class II molecules assemble in the endoplasmic reticulum in a chaperone-mediated
fashion to form a nine-chain structure consisting of three alpha beta dimers associated with …

The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from
human B-cell membranes has been determined by X-ray crystallography and is similar to …

An influenza virus peptide binds to HLA-DR1 in an extended conformation with a
pronounced twist. Thirty-five per cent of the peptide surface is accessible to solvent and …

The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the
treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead …

PEPTIDES bound to class I molecules are 8–10 amino acids long, and possess a binding
motif representative of peptides that bind to a given class I allele1–4. In the only published …

Peptide-protein interactions are very prevalent, mediating key processes such as signal
transduction and protein trafficking. How can peptides overcome the entropic cost involved …

T lymphocytes with rxf3 receptors recognize antigen in association with the polymorphic
products of the class I and class II loci of the major histocompatibility complex (MHC). This …

Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is commonly used
to obtain high resolution separation of complex mixtures of proteins. The method initially …

Abstract A complex between HLA-DR3 and a fragment of invariant chain called CLIP was
isolated from a human cell line defective in antigen presentation and its X-ray crystal …