The increasing understanding of the role of nitric oxide (NO) in cancer biology has
generated significant progress in the use of NO donor-based therapy to fight cancer. These …

Nitric oxide (NO), as an endogenous diatomic molecule, plays a key regulatory role in many
physiological and pathological processes. This diatomic free radical has been shown to …

Chemotherapy suffers numbers of limitations including poor drug solubility, nonspecific
biodistribution, and inevitable adverse effects on normal tissues. Tumor‐targeted delivery …

Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic
multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …

Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

On the basis of the strategy of creating multifunctional drugs, a novel series of
phenylsulfonylfuroxan-based hydroxamates with histone deacetylase (HDAC) inhibitory and …

Environmental pollutants like heavy metals are toxic, persistent, and bioaccumulative in
nature. Contamination of agricultural fields with heavy metals not only hampers the quality …

Twenty-three new coumarin-furoxan hybrids were synthesized, which exhibited nanomole
antiproliferation activities in A2780, A2780/CDDP, MCF-7/ADR, and MDA-MB-231. Among …

Brusatol, a biologically active natural product, was modified in four distinct positions through
the covalent attachment of a furoxan moiety, which acts as a nitric oxide (NO) donor. Forty …