High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock,
resection and transplantation, is a dynamic process that involves the two interrelated phases …

Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics,
cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic …

Extracellular high-mobility group box (HMGB) 1 mediates inflammation during sterile and
infectious injury and contributes importantly to disease pathogenesis. The first critical step in …

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known
best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule …

High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …

Background Acute glaucoma is a significantly sight-threatening cause of irreversible
blindness in the world characterized by a sudden and substantial intraocular pressure (IOP) …

Hepatic ischemia and reperfusion injury (I/R) is accompanied by excessive reactive oxygen
species and resultant sterile inflammation. Chlorogenic acid (CGA), one of the most …