[HTML][HTML] A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses

A Nassar, IM Ibrahim, FG Amin, M Magdy, AM Elgharib… - Molecules, 2021 - mdpi.com
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …

[HTML][HTML] New progresses on cell surface protein HSPA5/BiP/GRP78 in cancers and COVID-19

T Li, J Fu, J Cheng, AA Elfiky, C Wei, J Fu - Frontiers in Immunology, 2023 - frontiersin.org
Heat-shock-protein family A (Hsp70) member 5 (HSPA5), aliases GRP78 or BiP, is a protein
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …

[HTML][HTML] The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection

AJ Carlos, DP Ha, DW Yeh, R Van Krieken… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …

High GRP78 levels in Covid-19 infection: a case-control study

R Sabirli, A Koseler, T Goren, I Turkcuer, O Kurt - Life sciences, 2021 - Elsevier
Introduction Covid-19 infection was declared a global pandemic by WHO on March 11,
2020. GRP78 protein is known to be involved in the intrusion of numerous viruses. Our …

Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease …

M Ghasemzadeh, J Ahmadi, E Hosseini - Thrombosis research, 2022 - Elsevier
Platelet-leukocyte crosstalk is commonly manifested by reciprocal links between thrombosis
and inflammation. Platelet thrombus acts as a reactive matrix that recruits leukocytes to the …

Recognition through GRP78 is enhanced in the UK, South African, and Brazilian variants of SARS-CoV-2; An in silico perspective

IM Ibrahim, AA Elfiky, AM Elgohary - Biochemical and Biophysical …, 2021 - Elsevier
New SARS-CoV-2 variants emerged in the United Kingdom and South Africa in December
2020 in concomitant with the Brazillian variant in February 2021 (B. 1.1. 248 lineage) and …

GRP78: A possible relationship of COVID-19 and the mucormycosis; in silico perspective

AM Elgohary, AA Elfiky, K Barakat - Computers in Biology and Medicine, 2021 - Elsevier
Mucormycosis is a severe fungal infection reported in many cancer survivors, diabetic and
immune-suppressed patients during organ transplants. A vast spark in the reported COVID …

[HTML][HTML] SARS-CoV-2 delta variant is recognized through GRP78 host-cell surface receptor, in silico perspective

AA Elfiky, IM Ibrahim, AM Elgohary - International Journal of Peptide …, 2022 - Springer
Different SARS-CoV-2 new variants emerged and spread during the past few months,
sparking infections and death counts. The new variant B. 1.617 (delta variant) sparked in …

[HTML][HTML] Host-cell recognition of SARS-CoV-2 spike receptor binding domain from different variants

AA Elfiky, IM Ibrahim, MN Ibrahim… - The Journal of …, 2022 - ncbi.nlm.nih.gov
A recent letter in this journal described an avian influenza virus of wild bird origin that is well
adapted to a mammalian host, posing a potential threat to animal and human health. 1 This …

Role of serine proteases and host cell receptors involved in proteolytic activation, entry of SARS-CoV-2 and its current therapeutic options

G Dessie, T Malik - Infection and Drug Resistance, 2021 - Taylor & Francis
The current global pandemic of a novel severe acute respiratory syndrome coronavirus-2
continues with its public health disaster beginning from late December 2019 in Wuhan …