Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi)
effector proteins that are associated with a recently discovered group of small RNAs …

Organisms employ a fascinating array of strategies to silence invasive nucleic acids such as
transposons and viruses. Although evidence exists for several pathways that detect foreign …

Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a
wide variety of species. Here, we review studies from the last two decades addressing both …

Dicer is an essential component of RNA interference (RNAi) pathways, which have broad
functions in gene regulation and genome organization. Probing the consequences of tissue …

Prior studies have shown that disruption of mitochondrial electron transport chain (ETC)
function in the nematode Caenorhabditis elegans can result in life extension. Counter to …

We present a new concept in DNA engineering based on a pipeline of serial
recombineering steps in liquid culture. This approach is fast, straightforward and facilitates …

A key focus of evolutionary developmental biology (evo–devo) in recent years has been to
elucidate the evolution of developmental mechanisms as a means of reconstructing the …

RNA silencing in plants serves as a potent antiviral defense mechanism through the action
of small interfering RNAs (siRNAs), which direct RNA degradation. siRNAs can be derived …

Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number
of these elements are actively jumping in our genomes today. As a consequence, these …

One of the most thrilling experiments in biology is to introduce a gene of one's own design
into a favorite animal and examine the effect in the transgenic progeny. Methods to …