Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS)
levels, but how melatonin induces this ROS generation is unknown. In the present study, we …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

Stroke is one of the leading causes of death and disability worldwide. Brain injury after
ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress …

Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized
mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways …

Mitochondria damage is related to a broad spectrum of pathologies including Alzheimer's,
Parkinson's disease, and carcinogenesis. Recently, it has been found that reactive sulfur …

Highlights Hydrogen sulfide ameliorates TNF-α mediated endothelial dysfunction in human
endothelial cells by regulating the intrinsic apoptosis pathway. Beneficial effects of hydrogen …