Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Molecular docking is the most frequently used computational method for studying the
interactions between organic molecules and biological macromolecules. In this context …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …