The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …

The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular …

Voltage-gated sodium channels in brain neurons are complexes of a pore-forming a subunit
with smaller 81 and 82 subunits. cDNA cloning and sequencing showed that the 82 subunit …

Epilepsy is a common neurological condition that reflects neuronal hyperexcitability arising
from largely unknown cellular and molecular mechanisms. In generalized epilepsy with …

Inheritable long-QT syndrome (LQTS) is a disease in which delayed ventricular
repolarization leads to cardiac arrhythmias and the possibility of sudden death. In the …

Dorsal root ganglion neurons express a wide repertoire of sodium channels with different
properties. Here, we report the cloning from rat, dorsal root ganglia (DRG), cellular …

The cytoplasmic linker connecting domains III and IV of the voltage-gated Na+ channel is
thought to be involved in fast inactivation. This linker is highly conserved among the various …

1. Intracellular recordings in adult rat hippocampal slices were used to identify the ionic
conductances underlying active spike after‐depolarization (ADP) and intrinsic burst firing in …

The Drosophila para sodium channel α subunit was expressed in Xenopus oocytes alone
and in combination with tipE, a putative Drosophila sodium channel accessory subunit …

The structure of the ion conduction pathway or pore of voltage-gated ion channels is
unknown, although the linker between the membrane spanning segments S5 and S6 has …