Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

The genetic and molecular basis of ALS is increasingly examined on single-cell resolution.
In the past 2 years, the understanding of the downstream mechanisms of several ALS genes …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

Amyotrophic lateral sclerosis and Parkinson's disease are neurodegenerative diseases of
the motor system which are now recognized also to affect non-motor pathways. Non-motor …

Dozens of single nucleotide polymorphisms (SNPs) related to Alzheimer's disease (AD)
have been discovered by large scale genome-wide association studies (GWASs). However …

Amyotrophic lateral sclerosis (ALS) is caused by upper and lower motor neuron loss and
has a fairly rapid disease progression, leading to fatality in an average of 2-5 years after …

Motor neurons are a remarkably powerful cell type in the central nervous system. They
innervate and control the contraction of virtually every muscle in the body and their …

DNA is under constant attack from both endogenous and exogenous sources, and when
damaged, specific cellular signalling pathways respond, collectively termed the “DNA …

Amyotrophic lateral sclerosis (ALS) is regarded as a fatal neurodegenerative disease that is
featured by progressive damage of the upper and lower motor neurons. To date, over 45 …