Abstract Low Molecular Weight Heparins (LMWHs) are well-established for use in the
prevention and treatment of thrombotic diseases, and as a substitute for unfractionated …

Background Heparin-induced thrombocytopenia (HIT) is a serious complication caused by
heparin drugs. The ultralarge complexes formed by platelet factor 4 (PF4) with heparin or …

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy.
Antibodies binding to complexes of platelet factor 4 (PF4) and heparin is the trigger of HIT. A …

Structural analysis of proteins in a conformationally heterogeneous mixture has long been a
difficult problem in structural biology. In structural analysis by covalent labeling mass …

In this study, we evaluate the use of various two-dimensional liquid chromatographic
methods to characterize water-soluble, synthetically grafted bio-polymers, consisting of long …

During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a
crucial component of treatment alongside antivirus medications. Patients with severe COVID …

Structural analysis of proteins in a conformationally heterogeneous mixture has long been a
difficult problem in structural biology. In structural analysis by covalent labeling mass …

Hydroxyl radical protein footprinting (HRPF) is a method for probing the topography of
proteins in solution. A protein of interest is exposed to hydroxyl radicals freely diffusing in …