Macrophages play an important role in a wide variety of physiologic and pathologic
processes. Plasticity and functional polarization are hallmarks of macrophages …

Drinking alcohol, even in moderation, can affect the immune system. Studies have shown
disproportionate effects of alcohol on circulating and tissue-resident myeloid cells …

Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The
intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to …

Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8
million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death …

Alcohol misuse contributes to the dysregulation of immune responses and multiorgan
dysfunction across various tissues, which are associated with higher risk of morbidity and …

Annually, excessive alcohol use accounts for more than $220 billion in economic costs and
80,000 deaths, making excessive alcohol use the third leading lifestyle-related cause of …

Background Rosiglitazone, an exogenous ligand of PPARγ, plays an important anti-
inflammatory role during the inflammation caused by cigarette smoke (CS). CS exposure …

Excessive alcohol use increases the risk of developing respiratory infections partially due to
impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that …

The innate immunity has evolved during millions of years, and thus, equivalent or
comparable components are found in most vertebrates, invertebrates, and even plants. It …

Excessive alcohol users have increased risk of developing respiratory infections in part due
to oxidative stress-induced alveolar macrophage (AM) phagocytic dysfunction. Chronic …