Abstract T helper type 1 (Th1) lymphocytes secrete secrete interleukin (IL)-2, interferon-γ,
and lymphotoxin-α and stimulate type 1 immunity, which is characterized by intense …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Mycobacterium tuberculosis is one of the most ubiquitous pathogens in the world: estimates
are that roughly one third of the world's population is infected with the bacillus, and it is …

We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced
by human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ …

During TB cytokines play a role in host defence. To determine the cytokine pattern during
various disease stages of TB, serum levels of IL-12, interferon-gamma (IFN-γ), IL-4, IL-6 and …

Several genes coding for different cytokines may affect host susceptibility to tuberculosis.
This study investigates the relationship of the single base change polymorphic variants …

Tuberculosis (TB) has remained an unsolved problem and a major public health issue,
particularly in developing countries. Pakistan is one of the countries with the highest …

To characterize the mechanism by which interleukin 10 (IL-10) inhibits Th1 responses to
intracellular pathogens, we evaluated the interaction between IL-10 and Mycobacterium …

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated
peripheral blood mononuclear cells from tuberculosis patients had diminished production …

In tuberculosis, cellular immunity is considered to be responsible for the eradication of
infection but also for damage of host tissues. In animal models, the balance between Th1 …