The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Foxp3 (forkhead box P3 transcription factor)-expressing regulatory T cells (Tregs) are
essential for immunological tolerance, best illustrated by uncontrolled effector T-cell …

The mechanisms by which regulatory T (Treg) cells differentially control allergic and
autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had …

Foxp3 activity is essential for the normal function of the immune system. Two types of
regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and …

Oral immunotherapy has had limited success in establishing tolerance in food allergy,
reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease …

Regulatory T lymphocytes are essential to maintain homeostasis of the immune system,
limiting the magnitude of effector responses and allowing the establishment of …

Adaptive Foxp3+ CD4+ regulatory T (iTreg) cells develop outside the thymus under
subimmunogenic antigen presentation, during chronic inflammation, and during normal …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

The increasing rate of autoimmune disorders and cancer in recent years has been a
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …