This paper reviews some current methods for the in vivo assessment of local cutaneous
bioavailability in humans after topical drug application. After an introduction discussing the …

Over the past 30 or so years there has been a considerable advance in our knowledge of
the mechanisms of skin permeation. This has largely been brought about by the …

Tape stripping is a simple and efficient method for the assessment of quality and efficacy of
cosmetical and dermatological formulations. After topical application and penetration of …

Purpose. To determine whether and how encapsulation of lipophilic compounds in
polymeric nanoparticles is able to improve topical delivery to the skin. Methods. The …

Quantification of drugs within the skin is essential for topical and transdermal delivery
research. Over the last two decades, horizontal sectioning, consisting of tape stripping …

Due to the increased demand for reliable data regarding penetration into and permeation
across human skin, assessment of the absorption of xenobiotics has been gaining in …

Introduction Investigating the transportation of a drug molecule through various layers of skin
and determining the amount of drug retention in skin layers is of prime importance in …

Background Involved regions of the skin in patients with atopic dermatitis (AD) have been
shown to have higher transepidermal water loss (TEWL), indicating a compromised skin …

The aim of this work was to study, in vitro and in vivo, the behavior of a skin bioadhesive film
containing lidocaine. The film characterization included drug transport studies through skin …

Confocal Raman spectroscopy is being assessed as a tool with which to quantify the rate
and extent of drug uptake to and its clearance from target sites of action within the viable …