Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer
Q Sui, X Zhang, C Chen, J Tang, J Yu, W Li… - Nature …, 2022 - nature.com
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which
plays significant roles in tumor progression and immunosuppression. However, the …
plays significant roles in tumor progression and immunosuppression. However, the …
Pharmacogenomics of anti-TNF treatment response marks a new era of tailored rheumatoid arthritis therapy
T Wysocki, A Paradowska-Gorycka - International journal of molecular …, 2022 - mdpi.com
Rheumatoid arthritis (RA) is the most commonly occurring chronic inflammatory arthritis, the
exact mechanism of which is not fully understood. Tumor Necrosis Factor (TNF)-targeting …
exact mechanism of which is not fully understood. Tumor Necrosis Factor (TNF)-targeting …
Innate immune responses in pneumonia
FT Korkmaz, KE Traber - Pneumonia, 2023 - Springer
The lungs are an immunologically unique environment; they are exposed to innumerable
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …
Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling
Our aim was to determine whether rheumatoid arthritis (RA) low-density granulocytes
(LDGs) are functionally different from RA neutrophils. LDGs from 32 RA patients were …
(LDGs) are functionally different from RA neutrophils. LDGs from 32 RA patients were …
Weaning differentially affects mitochondrial function, oxidative stress, inflammation and apoptosis in normal and low birth weight piglets
AK Novais, K Deschêne, Y Martel-Kennes, C Roy… - PLoS …, 2021 - journals.plos.org
Weaning is associated with increased occurrence of infections and diseases in piglets.
Recent findings indicate that weaning induces mitochondrial dysfunction and oxidative …
Recent findings indicate that weaning induces mitochondrial dysfunction and oxidative …
Acute kidney injury induced lupus exacerbation through the enhanced neutrophil extracellular traps (and apoptosis) in Fcgr2b deficient lupus mice with renal ischemia …
W Saisorn, S Saithong, P Phuengmaung… - Frontiers in …, 2021 - frontiersin.org
Renal ischemia is the most common cause of acute kidney injury (AKI) that might be
exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here …
exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here …
Pathogen-associated molecules from gut translocation enhance severity of cecal ligation and puncture sepsis in iron-overload β-thalassemia mice
K Sae-Khow, A Charoensappakit… - Journal of …, 2020 - Taylor & Francis
Introduction Systemic inflammation induced by gut translocation of lipopolysaccharide
(LPS), a major component of Gram-negative bacteria, in thalassemia with iron-overload …
(LPS), a major component of Gram-negative bacteria, in thalassemia with iron-overload …
Defective neutrophil function in patients with sepsis is mostly restored by ex vivo ascorbate incubation
K Sae-Khow, S Tachaboon, HL Wright… - Journal of …, 2020 - Taylor & Francis
Background Neutrophil function is essential for effective defence against bacterial infections
but is defective in patients with sepsis. Ascorbate or vitamin C, which is low in the plasma of …
but is defective in patients with sepsis. Ascorbate or vitamin C, which is low in the plasma of …
PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role
Y Li, R Tan, R Li, R Tian, Z Liu, X Wang, E Chen… - Journal of …, 2023 - Springer
Background Delayed neutrophil apoptosis during sepsis may impact neutrophil organ
accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying …
accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying …
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease
JC Kash, KA Walters, J Kindrachuk, D Baxter… - Science translational …, 2017 - science.org
The 2013–2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was
unprecedented in the number of documented cases, but there have been few published …
unprecedented in the number of documented cases, but there have been few published …