The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Fragile X Syndrome (FXS) is a neurodevelopmental disorder and the leading monogenic
cause of autism and intellectual disability. For years, several efforts have been made to …

Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …

Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID)
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …

There are no approved medicines for fragile X syndrome (FXS), a monogenic,
neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in …

Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …

Abstract Autism Spectrum Disorders (ASD) encompass a wide array of debilitating
symptoms, including severe sensory deficits and abnormal language development. Sensory …

Background Sensory impairments commonly occur in patients with autism or intellectual
disability. Fragile X syndrome (FXS) is one form of intellectual disability that is often …

Recent failures translating preclinical behavioral treatment effects to positive clinical trial
results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological …

Fragile X syndrome (FXS) is a leading genetic cause of autism-like symptoms associated
with sensory hypersensitivity and cortical hyperexcitability. Recent observations in humans …