Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
Neurodevelopment and early pharmacological interventions in Fragile X Syndrome
LA Milla, L Corral, J Rivera, N Zuñiga, G Pino… - Frontiers in …, 2023 - frontiersin.org
Fragile X Syndrome (FXS) is a neurodevelopmental disorder and the leading monogenic
cause of autism and intellectual disability. For years, several efforts have been made to …
cause of autism and intellectual disability. For years, several efforts have been made to …
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
M Hooshmandi, V Sharma, CT Perez, R Sood… - Neuron, 2023 - cell.com
Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …
Fragile X Syndrome as an interneuronopathy: a lesson for future studies and treatments
A Tempio, A Boulksibat, B Bardoni… - Frontiers in …, 2023 - frontiersin.org
Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability (ID)
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …
and a primary genetic cause of autism spectrum disorder (ASD). FXS arises from the …
FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 …
TS Saraf, RP McGlynn, OM Bhatavdekar… - ACS chemical …, 2022 - ACS Publications
There are no approved medicines for fragile X syndrome (FXS), a monogenic,
neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in …
neurodevelopmental disorder. Electroencephalogram (EEG) studies show alterations in …
Matrix metalloproteinase‐9: A magic drug target in neuropsychiatry?
KT Kaczmarek, K Protokowicz… - Journal of …, 2023 - Wiley Online Library
Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …
of these conditions is very complex and combines genetic and environmental factors. The …
[HTML][HTML] Developmental trajectory and sex differences in auditory processing in a PTEN-deletion model of autism spectrum disorders
K Croom, JA Rumschlag, G Molinaro, MA Erickson… - Neurobiology of …, 2024 - Elsevier
Abstract Autism Spectrum Disorders (ASD) encompass a wide array of debilitating
symptoms, including severe sensory deficits and abnormal language development. Sensory …
symptoms, including severe sensory deficits and abnormal language development. Sensory …
[HTML][HTML] A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons
AJ Holley, A Shedd, A Boggs, J Lovelace… - Neurobiology of …, 2022 - Elsevier
Background Sensory impairments commonly occur in patients with autism or intellectual
disability. Fragile X syndrome (FXS) is one form of intellectual disability that is often …
disability. Fragile X syndrome (FXS) is one form of intellectual disability that is often …
[HTML][HTML] Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome
Recent failures translating preclinical behavioral treatment effects to positive clinical trial
results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological …
results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological …
Astrocytes regulate inhibition in Fragile X Syndrome
M Rais, AO Kulinich, V Wagner, W Woodard, XS Shuai… - bioRxiv, 2022 - biorxiv.org
Fragile X syndrome (FXS) is a leading genetic cause of autism-like symptoms associated
with sensory hypersensitivity and cortical hyperexcitability. Recent observations in humans …
with sensory hypersensitivity and cortical hyperexcitability. Recent observations in humans …