Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Genome instability, a hallmark of cancer progression, is thought to arise through DNA
double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …

Mediator is an essential, large, multisubunit, transcriptional co-activator highly conserved
across eukaryotes. Mediator interacts with gene-specific transcription factors at enhancers …

Defining the functional relationships between proteins is critical for understanding virtually
all aspects of cell biology. Large-scale identification of protein complexes has provided one …

The multisubunit Mediator (MED) complex bridges DNA-bound transcriptional regulators to
the RNA polymerase II (PolII) initiation machinery. In yeast, the 25 MED subunits are …

Like all microorganisms, yeast cells spend most of their natural lifetime in a reversible,
quiescent state that is primarily induced by limitation for essential nutrients. Substantial …

Iron is an essential element for all eukaryotes. The facile ability of iron to gain and lose
electrons permits its participation in a wide variety of oxidation-reduction reactions. Further …