Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …

Hypoxia has been identified as a common contributor to tumor progression, including
invasion and metastasis. However, the underlying mechanisms of enhanced invasion and …

Poly (ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in
the treatment of ovarian and breast cancers. PARP inhibitors are selectively active in cells …

Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which
contributes to drug resistance, necessitating development of novel therapeutic approaches …

Chromosome engineering has been attempted successfully in yeast but remains
challenging in higher eukaryotes, including mammals. Here, we report programmed …

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a
longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 …

Elucidating the physiological binding partners of histone post-translational modifications
(hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining …

High-grade gliomas with arginine or valine substitutions of the histone H3. 3 glycine-34
residue (H3. 3G34R/V) carry a dismal prognosis, and current treatments, including …