Crossroads of antibiotic resistance and biosynthesis

TA Wencewicz - Journal of molecular biology, 2019 - Elsevier
The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Highlights of the recent patent literature─ focus on biocatalysis innovation

DL Hughes - Organic Process Research & Development, 2022 - ACS Publications
This review surveys recent advances in biocatalysis, with a primary focus on contributions
from the patent literature since 2018, including reductive aminations, nitro reductions …

History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome

E Franck, TS Crofts - npj Antimicrobials and Resistance, 2024 - nature.com
The streptothricin antibiotics were among the first antibiotics to be discovered from the
environment and remain some of the most recovered antimicrobials in natural product …

Oxygen vacancies and Lewis sites activating O3/H2O2 at wide pH range via surface electron transfer over CeOx@ SiO2 for nitrobenzene mineralization

W Chen, J Xie, X Li, L Li - Journal of Hazardous Materials, 2021 - Elsevier
The low efficiency of peroxone (O 3/H 2 O 2) at acidic and neutral pH restrained its
application in water purification. To overcome this shortcoming, CeO X@ SiO 2 with large …

Genomic analysis of the Bacillus megaterium Mes11: New insights into nitroreductase genes associated with the degradation of mesotrione

L Carles, F Donnadieu, I Wawrzyniak… - International …, 2021 - Elsevier
Mesotrione is among the most recently marketed herbicides belonging to the triketone family
and applied on maize crops. A Bacillus megaterium Mes11 strain isolated from an …

Taking advantage of promiscuity of cold-active enzymes

SK Nandanwar, SB Borkar, JH Lee, HJ Kim - Applied Sciences, 2020 - mdpi.com
Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing
structural flexibility at or near the active sites. Inevitably, this feat seems to be accompanied …

Characteristics and catalytic mechanism of a novel multifunctional oxidase, CpmO, for chloramphenicols degradation from Sphingobium sp. WTD-1

Y Gao, H Cheng, Q Song, J Huang, J Liu, D Pan… - Journal of Hazardous …, 2024 - Elsevier
Chloramphenicols (CAPs) are ubiquitous emerging pollutants that threaten ecological
environments and human health. Microbial and enzyme-based biodegradation strategies …

One‐Pot Multienzyme Cascades for Stereodivergent Synthesis of Tetrahydroquinolines

A De, A Shukla, S Masood Husain - Angewandte Chemie, 2024 - Wiley Online Library
The tetrahydroquinoline (THQ) framework is commonly found in natural products and
pharmaceutically relevant molecules. Apart from using transition metal catalysts and chiral …

Functional and structural characterization of diverse NfsB chloramphenicol reductase enzymes from human pathogens

MW Mullowney, NI Maltseva, M Endres… - Microbiology …, 2022 - Am Soc Microbiol
Phylogenetically diverse bacteria can carry out chloramphenicol reduction, but only a single
enzyme has been described that efficiently catalyzes this reaction, the NfsB nitroreductase …

Efficient bio-reduction of 3-nitro phthalic acid using engineered nitroreductase and V2O5

Q Zhang, Y Feng, X Liang, S Wu, F He, Y Guan… - Process …, 2025 - Elsevier
In this study, a potent nitroreductase enzyme was successfully identified and engineered,
which was then employed in an efficient and environmentally friendly chemo-bio …