Maintenance of epithelial tissues needs the stroma. When the epithelium changes, the
stroma inevitably follows. In cancer, changes in the stroma drive invasion and metastasis …

The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …

Purpose: Generation of a reactive stroma environment occurs in many human cancers and
is likely to promote tumorigenesis. However, reactive stroma in human prostate cancer has …

During pancreatic tumor development, pancreatic stellate cells (PSCs) proliferate
exuberantly to secrete extracellular matrix (ECM) in the tumor stroma, which presents major …

Versican is a large extracellular matrix proteoglycan that is present in a variety of tissues.
Successful cloning of the gene in man, mouse, cow and chicken has revealed the existence …

The genomic, epigenetic and metabolic determinants of prostate cancer pathobiology have
been extensively studied in epithelial cancer cells. However, malignant cells constantly …

Increased expression of the proteoglycan, versican is strongly associated with poor outcome
for many different cancers. Depending on the cancer type, versican is expressed by either …

Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the
aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule …

Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer
development, ranging from proliferative signaling, evasion of growth-suppressor pathways …

Benign prostatic hyperplasia (BPH) is usually described as a pathological proliferation of
prostatic fibroblasts/myofibroblasts and epithelial cells. In the present study of BPH samples …