Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Background The primary issue arising from prostate cancer (PCa) is its high prevalence to
metastasize to bone, which severely affects the quality of life and survival time of PCa …

Abstract p53, circRNAs and miRNAs are important components of the regulatory network
that activates the EMT program in cancer metastasis. In prostate cancer (PCa), however, it …

Prostate cancer is a main urological disease associated with significant morbidity and
mortality. Radical prostatectomy and radiotherapy are potentially curative for localized …

Emerging studies indicated that cancer stem cells represent a subpopulation of cells within
the tumor that is responsible for chemotherapeutic resistance. However, the underlying …

The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

The microRNAs (miRNAs) are a class of small, 20–22 nucleotides in length, endogenously
expressed noncoding RNAs that regulate multiple targets posttranscriptionally. Interestingly …