[HTML][HTML] The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Type 2 diabetes mellitus-associated cognitive dysfunction: Advances in potential mechanisms and therapies

A Luo, Z Xie, Y Wang, X Wang, S Li, J Yan… - Neuroscience & …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

Inflammasomes as therapeutic targets for A lzheimer's disease

CS White, CB Lawrence, D Brough… - Brain …, 2017 - Wiley Online Library
Alzheimer's disease is the most common form of progressive dementia, typified initially by
short term memory deficits which develop into a dramatic global cognitive decline. The …

[HTML][HTML] Natural compounds as beneficial antioxidant agents in neurodegenerative disorders: A focus on Alzheimer's disease

A Amato, S Terzo, F Mulè - Antioxidants, 2019 - mdpi.com
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that
dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched …

[HTML][HTML] Obesity-related cognitive impairment: The role of endothelial dysfunction

JJ Buie, LS Watson, CJ Smith, C Sims-Robinson - Neurobiology of Disease, 2019 - Elsevier
Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …

[HTML][HTML] The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

Type 2 diabetes and Parkinson's disease: a focused review of current concepts

PW Cullinane, E de Pablo Fernandez… - Movement …, 2023 - Wiley Online Library
Highly reproducible epidemiological evidence shows that type 2 diabetes (T2D) increases
the risk and rate of progression of Parkinson's disease (PD), and crucially, the repurposing …

[HTML][HTML] From obesity-induced low-grade inflammation to lipotoxicity and mitochondrial dysfunction: altered multi-crosstalk between adipose tissue and metabolically …

G Cavaliere, F Cimmino, G Trinchese, A Catapano… - Antioxidants, 2023 - mdpi.com
Obesity is a major risk factor for several metabolic diseases, including type 2 diabetes,
hyperlipidemia, cardiovascular diseases, and brain disorders. Growing evidence suggests …