Alcohol consumption is known to cause several brain anomalies. The pathophysiological
changes associated with alcohol intoxication are mediated by various factors, most notable …

Neurodegenerative diseases are generally characterized clinically by the selective loss of a
distinct subset of neurons and a slow progressive course. Mounting evidence in vivo …

Alzheimer's disease (AD) is a central nervous system degenerative disease, with no
effective treatment to date. Administration of immune checkpoint inhibitors significantly …

Coronavirus disease 2019 (COVID-19) is now being investigated for its distinctive patterns
in the course of disease development which can be indicated with miscellaneous immune …

Ethanol has a complex effect on the cardiovascular system in humans, but the systemic
effects of ethanol to endothelial cells were rarely investigated. In this study, we exposed …

程序性死亡受体-1 (programmed death receptor-1, PD-1) 和程序性死亡配体-1 (programmed
death ligand-1, PD-L1) 是重要的免疫调节因子. PD-1 与PD-L1 结合可抑制T …

Diseases caused by a compromised immune system, characterized by decreased
production and diversification of T lymphocytes, such as immunodeficiencies or chronic …

Alcohol use and HIV-1 infection have a pervasive impact on brain function, which extends to
the requirement, distribution, and utilization of energy within the central nervous system. This …

Hemorrhage is a major component of traumatic brain injury (TBI). Red blood cells,
accumulated at the hemorrhagic site, undergo hemolysis upon energy depletion and …

Alcohol consumption in women enhances breast cancer incidence and ethanol is the main
causal factor. Compromised host immunity through immunosuppression facilitates the …