Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …

To achieve new breakthroughs in the development of synergistic antiviral medication
cocrystals of acyclovir (AYL) with phenolic acids, a cocrystallization-driven strategy for …

Abstract Carbamazepine (CBZ), a Biopharmaceutics Classification System (BCS) class II
drug, is widely-used as a first line antiepileptic drug. Numbers of cocrystals have reported to …

Herein, we reported a new bergenin: 4-aminobenzamide (BGN-4AM) cocrystal with
significantly enhanced solubility and low hygroscopicity probed from two aspects such as …

Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally
used for the preparation of cocrystals. However, even by using the same solvent, active …

Abstract Lamotrigine (LAM), a Biopharmaceutics Classification System (BCS) class II drug, is
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …

methylnicotinamide was utilized to create co-crystal/salts for the first time. By introducing it
into the co-crystallization system based on different carboxylic acids of mono-to dicarboxylic …

Based on literature analysis, we have built a database containing fusion temperatures and
enthalpies of two-component molecular co-crystals and individual compounds (2170 co …

Improving the solubility of poorly soluble drugs has always been a challenging subject in the
field of medicine. In this regard, a pharmaceutical cocrystal strategy has been considered to …

Abstract The 2-amino-5-methylthiazole was used in the construction of adducts. By
introducing it into the co-crystallization system based on different organic acids of mono-to …