[HTML][HTML] Sex differences underlying pancreatic islet biology and its dysfunction
M Gannon, RN Kulkarni, MT Hubert… - Molecular metabolism, 2018 - Elsevier
Background The sex of an individual affects glucose homeostasis and the pathophysiology,
incidence, and prevalence of diabetes as well as the response to therapy. Scope of the …
incidence, and prevalence of diabetes as well as the response to therapy. Scope of the …
CXCR3, CXCL10 and type 1 diabetes
A Antonelli, SM Ferrari, A Corrado, E Ferrannini… - Cytokine & growth factor …, 2014 - Elsevier
Abstract Type 1 diabetes (T1D) is due to antigen-specific assaults on the insulin producing
pancreatic β-cells by diabetogenic T-helper (Th) 1 cells.(CXC motif) ligand (CXCL) 10, an …
pancreatic β-cells by diabetogenic T-helper (Th) 1 cells.(CXC motif) ligand (CXCL) 10, an …
[PDF][PDF] PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease
ME Moreno-Fernandez, DA Giles, JR Oates, CC Chan… - Cell metabolism, 2021 - cell.com
Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD)
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …
Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes
T Rodriguez-Calvo, O Ekwall, N Amirian… - Diabetes, 2014 - Am Diabetes Assoc
Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and
environmental factors that have been implicated in the pathogenesis of disease both as …
environmental factors that have been implicated in the pathogenesis of disease both as …
HLA class II antigen processing and presentation pathway components demonstrated by transcriptome and protein analyses of islet β-cells from donors with type 1 …
Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T
cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we …
cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we …
[HTML][HTML] Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata
M Bertolini, F Zilio, A Rossi, P Kleditzsch… - PLoS …, 2014 - journals.plos.org
Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle
(HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are …
(HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are …
Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking
D Pham-Hua, LE Padgett, B Xue, B Anderson, M Zeiger… - Biomaterials, 2017 - Elsevier
Abstract Type 1 Diabetes (T1D) is a chronic pro-inflammatory autoimmune disease
consisting of islet-infiltrating leukocytes involved in pancreatic β-cell lysis. One promising …
consisting of islet-infiltrating leukocytes involved in pancreatic β-cell lysis. One promising …
The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
AL Bayer, A Pugliese, TR Malek - Immunologic research, 2013 - Springer
IL-2 plays a critical role in the normal function of the immune system. A trophic factor for
lymphocytes, IL-2 is required for mounting and sustaining adaptive T cell responses; …
lymphocytes, IL-2 is required for mounting and sustaining adaptive T cell responses; …
The beta cell-immune cell interface in type 1 diabetes (T1d)
EA James, AV Joglekar, AK Linnemann, HA Russ… - Molecular …, 2023 - Elsevier
Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
miRNA-16-5p inhibits the apoptosis of high glucose-induced pancreatic β cells via targeting of CXCL10: Potential biomarkers in type 1 diabetes mellitus
X Gao, S Zhao - Endokrynologia Polska, 2020 - journals.viamedica.pl
Introduction: We aimed to elucidate the relationship between CXC chemokine ligand 10
(CXCL10) and miR-16-5p, and their functions on the biological behaviour of type 1 diabetes …
(CXCL10) and miR-16-5p, and their functions on the biological behaviour of type 1 diabetes …