Purpose To review current literature on the renin-angiotensin system (RAS)-mediated
pathogenic mechanisms and therapeutic targets in ocular diseases. Methods A …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone
system (RAAS) and have a central role in hypertension as well as cardiovascular and renal …

In the present review we examine the experimental and clinical evidence for the presence of
a local renin–angiotensin system within the retina. Interest in a pathogenic role for the renin …

Ion channels and ion transporters play essential roles in the function of the retinal pigment
epithelium (RPE). The use of cell cultures has been exploited as a key method for …

Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-
proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and …

Purpose: The purpose of this study was to determine the relative expression of clinically-
relevant components of the renin-angiotensin system (RAS) in the adult human eye …

Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC)
death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We …

The renin–angiotensin system (RAS) is most well-known for its role in regulation and
dysregulation of blood pressure as well as fluid and electrolyte homeostasis. Due to its …

Inflammation is associated with retinal diseases. Our recent data demonstrate that
immunoproteasome catalytic subunit β2i contributes to angiotensin II (Ang II)-induced …