Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease
Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …
Advanced tests for early and accurate diagnosis of Creutzfeldt–Jakob disease
G Zanusso, S Monaco, M Pocchiari… - Nature Reviews …, 2016 - nature.com
Early and accurate diagnosis of Creutzfeldt–Jakob disease (CJD) is a necessary to
distinguish this untreatable disease from treatable rapidly progressive dementias, and to …
distinguish this untreatable disease from treatable rapidly progressive dementias, and to …
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies
The clinical diagnosis of synucleinopathies, including Parkinson's disease (PD), dementia
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
BR Groveman, CD Orrù, AG Hughson… - Acta neuropathologica …, 2018 - Springer
The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …
Diagnosis of human prion disease using real-time quaking-induced conversion testing of olfactory mucosa and cerebrospinal fluid samples
M Bongianni, C Orrù, BR Groveman… - JAMA …, 2017 - jamanetwork.com
Importance Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is
necessary for quickly distinguishing treatable from untreatable rapidly progressive …
necessary for quickly distinguishing treatable from untreatable rapidly progressive …
Seed amplification and neurodegeneration marker trajectories in individuals at risk of prion disease
Human prion diseases are remarkable for long incubation times followed typically by rapid
clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are …
clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are …
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
A Kraus, E Saijo, MA Metrick, K Newell… - Acta …, 2019 - Springer
Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal
accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat …
accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat …
Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid
The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer
disease and certain frontotemporal dementias is hampered by the inability to detect …
disease and certain frontotemporal dementias is hampered by the inability to detect …
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
CD Orrú, J Yuan, BS Appleby, B Li, Y Li… - Science translational …, 2017 - science.org
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases
Multiple neurodegenerative diseases are characterized by aggregation of tau molecules.
Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding …
Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding …