Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …

Background The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases,
including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor …

The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

Autoinflammatory diseases are characterised by fever and systemic inflammation, with
potentially serious complications. Owing to the rarity of these diseases, evidence-based …

Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …

Background Pyoderma gangrenosum (PG) is a rare skin disease characterized clinically by
ulcers with undermined borders, and histologically by neutrophil‐rich infiltrates. PG may …

The NLRP3 inflammasome is one of the NOD-like receptor family members with the most
functional characterization and acts as a key player in innate immune system, participating …

The cryopyrin-associated periodic syndromes (CAPS) are usually caused by heterozygous
NLRP3 gene variants, resulting in excessive inflammasome activation with subsequent …

Periodic fever syndromes are autoinflammatory diseases. The majority present in infancy or
childhood and are characterised by recurrent episodes of fever and systemic inflammation …