Clonal expansion in non-cancer tissues
N Kakiuchi, S Ogawa - Nature Reviews Cancer, 2021 - nature.com
Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
[HTML][HTML] UV radiation and the skin
J D'Orazio, S Jarrett, A Amaro-Ortiz, T Scott - International journal of …, 2013 - mdpi.com
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …
High burden and pervasive positive selection of somatic mutations in normal human skin
How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Field cancerization: Definition, epidemiology, risk factors, and outcomes
TJ Willenbrink, ES Ruiz, CM Cornejo… - Journal of the American …, 2020 - Elsevier
Field cancerization was first described in 1953 when pathologic atypia was identified in
clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated …
clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated …
Outcompeting cancer
M Vishwakarma, E Piddini - Nature Reviews Cancer, 2020 - nature.com
The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …
environment, and indeed throughout epithelial tissues, cells experience competition with …
Correction of aberrant growth preserves tissue homeostasis
Cells in healthy tissues acquire mutations with surprising frequency. Many of these
mutations are associated with abnormal cellular behaviours such as differentiation defects …
mutations are associated with abnormal cellular behaviours such as differentiation defects …
Non-melanoma skin cancer: what drives tumor development and progression?
P Boukamp - Carcinogenesis, 2005 - academic.oup.com
Non-melanoma skin cancer, ie basal cell carcinoma (BCC) and squamous cell carcinoma
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …
Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma
GT Gibney, JL Messina, IV Fedorenko… - Nature reviews Clinical …, 2013 - nature.com
The clinical benefits of BRAF inhibition in patients with advanced-stage BRAF-mutant
melanoma are now well established. Although the emergence of cutaneous squamous-cell …
melanoma are now well established. Although the emergence of cutaneous squamous-cell …
Regional analysis of p53 mutations in rheumatoid arthritis synovium
Y Yamanishi, DL Boyle, S Rosengren… - Proceedings of the …, 2002 - National Acad Sciences
The p53 tumor suppressor protein plays a central role in cell cycle regulation, DNA repair,
and apoptosis. Recent studies indicate that DNA damage and somatic mutations in the p53 …
and apoptosis. Recent studies indicate that DNA damage and somatic mutations in the p53 …