Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and
a non-specific damaging agent and has properties of both a tumor initiator and a tumor …

How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Field cancerization was first described in 1953 when pathologic atypia was identified in
clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated …

The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …

Cells in healthy tissues acquire mutations with surprising frequency. Many of these
mutations are associated with abnormal cellular behaviours such as differentiation defects …

Non-melanoma skin cancer, ie basal cell carcinoma (BCC) and squamous cell carcinoma
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …

The clinical benefits of BRAF inhibition in patients with advanced-stage BRAF-mutant
melanoma are now well established. Although the emergence of cutaneous squamous-cell …

The p53 tumor suppressor protein plays a central role in cell cycle regulation, DNA repair,
and apoptosis. Recent studies indicate that DNA damage and somatic mutations in the p53 …