Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Approximately one‐half of patients with newly diagnosed cancer and many patients with
persistent or recurrent tumors receive radiotherapy (RT), with the explicit goal of eliminating …

Radiation therapy (RT) is used in the management of several cancers; however, tumor
radioresistance remains a challenge. Polymorphonuclear neutrophils (PMNs) are recruited …

Risks of tumor recurrence after surgical resection have been known for decades, but the
mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line …

Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …

Background & Aims The mechanisms of hypoxia-induced tumor growth remain unclear.
Hypoxia induces intracellular translocation and release of a variety of damage associated …

The transcription factor signal transducer and activator of transcription (STAT) 3 is activated
downstream of cytokines, growth factors and oncogenes to mediate their functions under …

Purpose: Recent advances in immunotherapy of advanced human cancers underscored the
need to address and eliminate tumor immune evasion. The myeloid-derived suppressor …

The immune system has the power to modulate the expression of radiation-induced normal
and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the …